Structural Probes of HIV, MMLV, and AMV Reverse Transcriptases
نویسندگان
چکیده
منابع مشابه
Base Preferences in Non-Templated Nucleotide Incorporation by MMLV-Derived Reverse Transcriptases
Reverse transcriptases derived from Moloney Murine Leukemia Virus (MMLV) have an intrinsic terminal transferase activity, which causes the addition of a few non-templated nucleotides at the 3' end of cDNA, with a preference for cytosine. This mechanism can be exploited to make the reverse transcriptase switch template from the RNA molecule to a secondary oligonucleotide during first-strand cDNA...
متن کاملLetter to the Editor Potential Structural Motifs for Reverse Transcriptases
Recently, Xiong and Eickbush ( 1988) generated a detailed primary sequence alignment of RNA-directed DNA polymerases ( rd’s) . The rd’s, or reverse transcriptases, are essential enzymes of retroviruses, and recent evidence for reverse transcription has been obtained for other genetic elements, including DNA viruses, transposable elements, and introns (see refs. in Xiong and Eickbush 1988). The ...
متن کاملComprehensive Phylogenetic Analysis of Bacterial Reverse Transcriptases
Much less is known about reverse transcriptases (RTs) in prokaryotes than in eukaryotes, with most prokaryotic enzymes still uncharacterized. Two surveys involving BLAST searches for RT genes in prokaryotic genomes revealed the presence of large numbers of diverse, uncharacterized RTs and RT-like sequences. Here, using consistent annotation across all sequenced bacterial species from GenBank an...
متن کاملComparative studies of the inhibitory properties of antibiotics on human immunodeficiency virus and avian myeloblastosis virus reverse transcriptases and cellular DNA polymerases.
The inhibition of human immunodeficiency virus (HIV) reverse transcriptase by certain antibiotics and related compounds was studied in comparison with that of avian myeloblastosis virus (AMV) reverse transcriptase and cellular DNA polymerases alpha and beta. In general, compounds that inhibited HIV reverse transcriptase also inhibited AMV reverse transcriptase. For example, 10 micrograms/ml of ...
متن کاملScheme DSS [ NIST ] AMV [ AMV ]
Emerging applications like electronic commerce and secure communications over open networks have made clear the fundamental role of public key cryptography as a unique enabler for worldwide scale security solutions. On the other hand, these solutions clearly expose the fact that the protection of private keys is a security bottleneck in these sensitive applications. This problem is further wors...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.5.a903-c